Article Publish Status: FREE
Abstract Title:

Identification of compounds with antipyretic effects and anti-endotoxin activity in different species ofusing spectrum-effect correlation.

Abstract Source:

Exp Ther Med. 2021 Jul ;22(1):665. Epub 2021 Apr 22. PMID: 33986830

Abstract Author(s):

Jing-Xin Ding, Chang Liu, Xiong-Wei Liu, Wei-Na Yan, Wen-Pei Li, Hui Shi, Jia-Xin Li, Cheng-Lin Tang, Ying Zhou

Article Affiliation:

Jing-Xin Ding


Liquid chromatography (LC) is a common and straight forward approach used in the evaluation of the quality of Traditional Chinese Medicines (TCMs). Quality control is a critical step when systematically assessing the efficacy of TCMs. In the present study, the spectrum-effect correlation method was used to identify pharmacologically active substances. The aim of the present study was to investigate the underlying correlations between common chemical compounds with antipyretic effects and the anti-endotoxin activity of. The common chemical constituents ofwere analyzed using LC, and the antipyretic effects and anti-endotoxin activity were determined using ELISAs. Combining the results of bivariate and principal component analysis methods, eight active constituents were qualitatively and quantitatively analyzed. The results of these analyses indicated that neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and isochlorogenic acids A, B and C served a synergistic role with respect to antipyretic effects and anti-endotoxin activity. The present study lays a foundation for the future clinical use of.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-pyretic : CK(62) : AC(24)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & receive The Dark Side of Wheat Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.