Abstract Title:

Identification of degranulation inhibitors from rooibos (Aspalathus linearis) tea in rat basophilic leukaemia cells.

Abstract Source:

Nat Prod Res. 2017 Dec 20:1-5. Epub 2017 Dec 20. PMID: 29262735

Abstract Author(s):

Yuta Morishita, Kaoru Ikeda, Hiroaki Matsuno, Hideyuki Ito, Akihiro Tai

Article Affiliation:

Yuta Morishita


Quercetin, luteolin and chrysoeriol were identified from rooibos tea as degranulation inhibitors in rat basophilic leukaemia cells. The degranulation inhibitory activity of chrysoeriol was first discovered in the present study. When quercetin, luteolin and chrysoeriol were mixed in the ratio that occurs in rooibos tea extract, the mixture inhibited antigen- and calcium ionophore-stimulated degranulation to the same degree as that by the whole rooibos tea extract. These findings indicate that these three flavonoids are the key factors underlying the degranulation inhibitory activity of rooibos tea.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Chemotherapeutic : CK(2328) : AC(1086)

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