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Article Publish Status: FREE
Abstract Title:

Identification of Genipin as a Potential Treatment for Type 2 Diabetes.

Abstract Source:

Int J Mol Sci. 2023 Jan 21 ;24(3). Epub 2023 Jan 21. PMID: 36768454

Abstract Author(s):

Yajun Wu, Yao Wang, Dongmin Liu

Article Affiliation:

Yajun Wu

Abstract:

The prevalence of type 2 diabetes (T2D) has been rising dramatically in many countries around the world. The main signatures of T2D are insulin resistance and dysfunction ofβ-cells. While there are several pharmaceutical therapies for T2D, no effective treatment is available for reversing the functional decline of pancreaticβ-cells in T2D patients. It has been well recognized that glucagon-like peptide-1 (GLP-1), which is an incretin hormone secreted from intestinal L-cells, plays a vital role in regulating glycemic homeostasis via potentiating glucose-stimulated insulin secretion and promotingβ-cell function. We found that genipin, a natural compound from Elli, can directly target intestinal L-cells, leading to the secretion of GLP-1. Incubation of the cells with genipin elicited a rapid increase in intracellular Ca. Inhibition of PLC ablated genipin-stimulated Caincrease and GLP-1 secretion, suggesting that genipin-induced GLP-1 release from cells is dependent on the PLC/Capathway. In vivo, acute administration of genipin stimulated GLP-1 secretion in mice. Chronically, treatment with genipin via oral gavage at 50 mg/kg/day for 6 weeks reversed hyperglycemia and insulin resistance in high-fat-diet (HFD)-induced obese mice. Moreover, genipin alleviated the impaired lipid metabolism and decreased lipid accumulation in the liver of obese mice. These results suggest that naturally occurring genipin might potentially be a novel agent for the treatment of T2D and diet-induced fatty liver disease.

Study Type : Animal Study

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