Article Publish Status: FREE
Abstract Title:

Identification of a Novel Oligosaccharide in Maple Syrup as a Potential Alternative Saccharide for Diabetes Mellitus Patients.

Abstract Source:

Int J Mol Sci. 2019 Oct 11 ;20(20). Epub 2019 Oct 11. PMID: 31614552

Abstract Author(s):

Kanta Sato, Noriaki Nagai, Tetsushi Yamamoto, Kuniko Mitamura, Atsushi Taga

Article Affiliation:

Kanta Sato


The incidence of diabetes mellitus (DM) is increasing rapidly and is associated with changes in dietary habits. Although restrictions in the use of sweeteners may prevent the development of DM, this might reduce the quality of life of patients with DM. Therefore, there has been a great deal of research into alternative sweeteners. In the search for such sweeteners, we analyzed the carbohydrate content of maple syrup and identified a novel oligosaccharide composed of fructose and glucose, linked at the C-4 of glucose and the C-6 of fructose. This oligosaccharide inhibited the release of fructose from sucrose by invertase (IC: 1.17 mmol/L) and the decomposition of maltose byα-(1-4) glucosidase (IC: 1.72 mmol/L). In addition, when orally administered together with sucrose to rats with DM, the subsequent plasma glucose concentrations were significantly lower than if the rats had been administered sucrose alone, without having any effect on the insulin concentration. These findings suggest that this novel oligosaccharide might represent a useful alternative sweetener for inclusion in the diet of patients with DM and may also have therapeutic benefits.

Study Type : Animal Study

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