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Abstract Title:

Immunodeficiency Accelerates Vitamin A Deficiency.

Abstract Source:

Curr Dev Nutr. 2021 Nov ;5(11):nzab129. Epub 2021 Oct 27. PMID: 34870072

Abstract Author(s):

Luigi M De Luca, Victoria Hill Petrides, Nadine Darwiche, Laura Armey, Amanda Palmer, Keith P West

Article Affiliation:

Luigi M De Luca


Background: Vitamin A deficiency increases susceptibility to infection caused by impaired immune function.

Objectives: We investigated whether immunodeficiency could facilitate the development of vitamin A deficiency.

Methods: Vitamin A deficiency was followed in 2 mouse models of immunodeficiency: the athymic nude mouse () and the humoral immunodeficient SENCAR (SENsitive to CARcinogenesis) mouse. Vitamin A deficiency was also monitored in outbred Balb/c and in NIH mice. The monitoring of vitamin A deficiency was done after feeding the mice and their mothers a semisynthetic, vitamin A-deficient diet from birth of the experimental mice. These mice were weaned onto the same deficient diet at 3-4 wk of age, while control groups were fed the same diet containing 3μg retinoic acid per gram of diet.

Results: The immunodeficientand SENCAR mice developed vitamin A deficiency earlier than either the heterozygouscontrols or the Balb/c and NIH strains. In female mice, symptoms included depletion of liver retinol and retinyl palmitate, squamous metaplasia of the uterus, and death. Male mice lost weight more frequently and sooner than female mice, in which mortality generally occurred in the absence of loss of body weight. Pairwise comparisons using Tukey's honest significant difference test of theand SENCAR mice versus the Balb/c and NIH mice showed a faster loss of retinol and retinyl palmitate in all pairs (≤ 0.0001) except for retinol when comparingand NIH strains (= 0.3383).

Conclusions: Our findings are consistent with an increased usage of liver retinol and retinyl palmitate in the immunocompromisedand in the immunodeficient SENCAR mice and suggest that compensatory mechanisms dependent on vitamin A utilization are called upon to rescue immunodeficiency both in the T-cell-deficient phenotype of themice and in the humoral immunodeficient SENCAR mice.

Study Type : Animal Study
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