n/a
Article Publish Status: FREE
Abstract Title:

Immunological imprint of COVID-19 on human peripheral blood leukocyte populations.

Abstract Source:

Allergy. 2020 Oct 31. Epub 2020 Oct 31. PMID: 33128792

Abstract Author(s):

Bernhard Kratzer, Doris Trapin, Paul Ettel, Ulrike Körmöczi, Arno Rottal, Friedrich Tuppy, Melanie Feichter, Pia Gattinger, Kristina Borochova, Yulia Dorofeeva, Inna Tulaeva, Milena Weber, Katharina Grabmeier-Pfistershammer, Peter A Tauber, Marika Gerdov, Bernhard Mühl, Thomas Perkmann, Ingrid Fae, Sabine Wenda, Harald Führer, Rainer Henning, Rudolf Valenta, Winfried F Pickl

Article Affiliation:

Bernhard Kratzer

Abstract:

BACKGROUND: SARS-CoV-2 has triggered a pandemic that is now claiming many lives. Several studies have investigated cellular immune responses in COVID-19-infected patients during disease but little is known regarding a possible protracted impact of COVID-19 on the adaptive and innate immune system in COVID-19 convalescent patients.

METHODS: We used multiparametric flow cytometry to analyze whole peripheral blood samples and determined SARS-CoV-2-specific antibody levels against the S-protein, its RBD-subunit, and viral nucleocapsid in a cohort of COVID-19 convalescent patients who had mild disease ~10 weeks after infection (n = 109) and healthy control subjects (n = 98). Furthermore, we correlated immunological changes with clinical and demographic parameters.

RESULTS: Even ten weeks after disease COVID-19 convalescent patients had fewer neutrophils, while their cytotoxic CD8T cells were activated, reflected as higher HLA-DR and CD38 expression. Multiparametric regression analyses showed that in COVID-19-infected patients both CD3CD4and CD3CD8effector memory cells were higher, while CD25Foxp3T regulatory cells were lower. In addition, both transitional B cell and plasmablast levels were significantly elevated in COVID-19-infected patients. Fever (duration, level) correlated with numbers of central memory CD4T cells and anti-S and anti-RBD, but not anti-NC antibody levels. Moreover, a"young immunological age"as determined by numbers of CD3CD45RACD62LCD31recent thymic emigrants was associated with a loss of sense of taste and/or smell.

CONCLUSION: Acute SARS-CoV-2 infection leaves protracted beneficial (ie, activation of T cells) and potentially harmful (ie, reduction of neutrophils) imprints in the cellular immune system in addition to induction of specific antibody responses.

Study Type : Animal Study
Additional Links
Additional Keywords : Immune Memory

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.