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Abstract Title:

Immunomodulating Properties of Carrageenan from Tichocarpus crinitus.

Abstract Source:

Inflammation. 2020 Mar 24. Epub 2020 Mar 24. PMID: 32212036

Abstract Author(s):

Eduardas Cicinskas, Aleksandra A Kalitnik, Yuriy A Karetin, Manoj Saravana Guru Mohan Ram, Anant Achary, Anna O Kravchenko

Article Affiliation:

Eduardas Cicinskas

Abstract:

Several in vivo immunotropic effects ofκ/β-carrageenan isolated from the red algae Tichocarpus crinitus were studied, by orally administering it at 100 mg/kg/day to mice for 7 days. Serum levels of IFN-γ, IL-12, IL-1β, and IL-4 were measured. Carrageenan's ability to influence development of LPS-induced inflammation was also assessed. Oral administration of κ/β-carrageenan increased serum levels of all the studied cytokines at least twice in comparison to the intact mice, while intraperitoneal LPS injection at 1 mg/kg increased concentration of only the pro-inflammatory cytokines: IFN-γ, IL-12, and IL-1β. Furthermore, κ/β-carrageenan demonstrated a higher efficacy at inducing IFN-γ production than LPS. Previous 7-day-long oral carrageenan administration impaired development of LPS-induced inflammation: level of IL-1β dropped below that found in intact mice, while IFN-γ and IL-12 concentrations were at least 40% lower than in mice with LPS-induced inflammation. Murine peritoneal macrophages were also affected by the oral administration of the κ/β-carrageenan: their motility was increased, and morphology altered. In sum, we have demonstrated that κ/β-carrageenan, when administered orally, is not only not immunologically inert, but at the dose of 100 mg/kg possesses pharmacologically exploitable effects.

Study Type : Animal Study, In Vitro Study

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