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Abstract Title:

Immunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus.

Abstract Source:

J Pharm Pharmacol. 2020 Nov ;72(11):1657-1665. Epub 2020 Aug 5. PMID: 32757490

Abstract Author(s):

Grace Gar-Lee Yue, Xin-Xin Liang, Xiao-Li Li, Julia Kin-Ming Lee, Si Gao, Hin-Fai Kwok, Clara Bik-San Lau, Wei-Lie Xiao

Article Affiliation:

Grace Gar-Lee Yue

Abstract:

OBJECTIVES: Two labdane diterpenoids, leojapone B and heteronone B, were isolated from Leonurus japonicus Houtt., and their biological activity were evaluated in this study.

METHODS: Human and mouse cancer cells, human peripheral blood mononuclear cells (PBMCs) and mouse macrophages (RAW264.7 cells) were used to evaluate the activity of leojapone B and heteronone B, while the in vivo effects of leojapone B were further examined in Lewis Lung Cancer tumour-bearing mice.

KEY FINDINGS: In vitro studies showed that leojapone B selectively inhibited the proliferation of lung cancer cells, and both leojapone B and heteronone B inhibited the production of pro-inflammatory cytokines in activated PBMCs. In tumour-bearing mice model, lung tumours were reduced in size in mice treated with intraperitoneal injections of leojapone B at 20 and 30 mg/kg for 14 days. The population ratio of CD4/CD8T cells in mouse spleens was found to be increased, while regulatory T cells were decreased after leojapone B treatment.

CONCLUSIONS: The inhibitory effects of leojapone B in mouse lung tumours were demonstrated for the first time in this study. The immunomodulatory activity of heteronone B were also demonstrated. Our findings indicated that both leojapone B and heteronone B may act as active components in L. japonicus.

Study Type : Animal Study, In Vitro Study

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