Abstract Title:

Immunomodulatory effects of hydroxyethylated Hericium erinaceus polysaccharide on macrophages RAW264.7.

Abstract Source:

Int J Biol Macromol. 2017 Jul 18. Epub 2017 Jul 18. PMID: 28729219

Abstract Author(s):

Zhe Ren, Tao Qin, Fuan Qiu, Yulong Song, Dandan Lin, Yufang Ma, Jian Li, Yifan Huang

Article Affiliation:

Zhe Ren


Hericium erinaceus polysaccharide (HEP) has been shown to possess a variety of biological activities. In present study, HEP was successfully modified to obtain its hydroxyethylated derivative hHEP. Its potential immunomodulatory activities on RAW264.7 macrophages were investigated. Results showed that the hHEP were significantly stronger than that of the corresponding unmodified polysaccharide, HEP. Meanwhile, the NO, IL-6 and TNF-α production activities of macrophages were enhanced in the RAW264.7 macrophages by stimulation of hHEP. In addition, the hHEP increase significantly higher iNOS expression than HEP. These results indicated that the hydroxyethylated derivative hHEP could enhance the activation of peritoneal macrophages, and hydroxyethylation modification can enhance the immunomodulation function of HEP.

Study Type : In Vitro Study

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