The Immunomodulatory Effects of Royal Jelly on Defending Against Bacterial Infections in theModel.
J Med Food. 2020 Jul 17. Epub 2020 Jul 17. PMID: 32701017
Emerging evidence suggests that aging is associated with the deterioration of immunity, a term known as immunosenescence, which may lead to a higher incidence of infections in the elderly population. Our previous studies reported that supplementation of royal jelly (RJ) extended the lifespan of(), a nematode model. The aim of this study was to investigate the potential benefits of RJ supplementation on modulation of the innate immunity in. Using(; ATCC 25923) as the infection model, we showed that RJ supplementation from the egg hatching stage could protectagainst the infection. Further mechanistic studies demonstrated that RJ coordinated pathways of IIS/DAF-16, p38 MAPK, and Wnt to modulate the innate immunity. In addition, when RJ was administrated to the aged, the worms displayed prolonged survival time to a variety of bacterial infections compared with the nontreatment group. This result indicates the RJ may help delay the innate immunosenescence.