Article Publish Status: FREE
Abstract Title:

Impact of Berberine on Some Epigenetic, Transcription Regulation and Inflammatory Biomarkers in a Mice Model of Epilepsy.

Abstract Source:

Rep Biochem Mol Biol. 2021 Oct ;10(3):362-372. PMID: 34981012

Abstract Author(s):

Heba Bassiony Ghanem, Marwa Nagy Emam, Ali Dareen Abdelaziz Mohammed, Abd-Ellatif Rania Nagi

Article Affiliation:

Heba Bassiony Ghanem


Background: Epilepsy is one of the most widespread neurological disease worldwide. Status epilepticus (SE) is a life-threatening neurologic disorder. Neuroprotective approaches are increasingly to discover a promising therapy to manage epileptic disorders. This study aimed to assess the impact of berberine on some epigenetic, transcription regulation&inflammatory biomarkers in a mice model of epilepsy.

Methods: This work was performed on; Group I: (control), Group II: berberine-treated control,Group III: epilepsy group, Group IV: berberine-treated epilepsy. Groups were subjected to assessment of Tumor growth factor-1β (TGF-1β), hypoxia inducible factor-1α (HIF-1α), brain derived neurotrophic factor (BDNF) levels, histone deacetylase (HDAC) activity&neuronal restrictive silencing factor (NRSF) gene expression.

Results: Study showed significant increase in levels of HIF-1α, TGF-1β, HDAC activity&NRSF gene expression in epilepsy group&decrease in these levels in berberine treated epilepsy group. Significant decrease in BDNF levels in epilepsy&elevation in them in berberine treated epilepsy group.

Conclusion: Our study showed the anti-epileptic impact of berberine via its regulatory effect on some epigenetic, transcription factors&inflammatory biomarkers in a mice model of epilepsy.

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