Article Publish Status: FREE
Abstract Title:

Impact of Phlorotannin Extracts fromon Human Gut Microbiota.

Abstract Source:

Mar Drugs. 2021 Jun 29 ;19(7). Epub 2021 Jun 29. PMID: 34209623

Abstract Author(s):

Marcelo D Catarino, Catarina Marçal, Teresa Bonifácio-Lopes, Débora Campos, Nuno Mateus, Artur M S Silva, Maria Manuela Pintado, Susana M Cardoso

Article Affiliation:

Marcelo D Catarino


Recent studies indicate that plant polyphenols could be pointed as potential prebiotic candidates since they may interact with the gut microbiota, stimulating its growth and the production of metabolites. However, little is known about the fate of brown seaweeds' phlorotannins during their passage throughout the gastrointestinal tract. This work aimed to evaluate the stability and bioaccessibility ofphlorotannins after being submitted to a simulated digestive process, as well as their possible modulatory effects on gut microbiota and short-chain fatty acids production following a fermentation procedure using fecal inoculates to mimic the conditions of the large intestine. The stability of phlorotannins throughout the gastrointestinal tract was reduced, with a bioaccessibility index between 2 and 14%. Moreover, slight alterations in the growth of certain commensal bacteria were noticed, withspp. being the most enhanced group. Likewise,phlorotannins displayed striking capacity to enhance the levels of propionate and butyrate, which are two important short-chain fatty acids known for their role in intestinal homeostasis. In summary, this work provides valuable information regarding the behavior ofphlorotannins along the gastrointestinal tract, presenting clear evidence that these compounds can positively contribute to the maintenance of a healthy gastrointestinal condition.

Study Type : Animal Study

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