Abstract Title:

Impact of saffron (Crocus Sativus Linn) supplementation and resistance training on markers implicated in depression and happiness levels in untrained young males.

Abstract Source:

Physiol Behav. 2021 Feb 6 ;233:113352. Epub 2021 Feb 6. PMID: 33556410

Abstract Author(s):

Babak Hooshmand Moghadam, Reza Bagheri, Behnam Roozbeh, Damoon Ashtary-Larky, Abbas Ali Gaeini, Frédéric Dutheil, Alexei Wong

Article Affiliation:

Babak Hooshmand Moghadam


BACKGROUND: We aimed to assess the effects of six weeks of resistance training (RT) combined with saffron supplementation on markers implicated in depression as well as happiness levels in untrained young males.

MATERIALS AND METHODS: Untrained young male participants were randomly assigned to one of two groups: RT + saffron supplement (RS; n = 14) or RT + placebo (RP; n = 14). For 6 weeks, participants in the RS group took one 150 mg pill of pure saffron immediately after each RT session and at the same time on non-training days. Those assigned to the RP group took a dextrose pill. Concentrations of Anandamide (AEA), 2-Arachidonoylglycerol (2-AG), serotonin, dopamine, β-endorphin (beta-endorphin), tryptophan, happiness levels (via questionnaire), and body composition were assessed before and after the 6 weeks of whole-body supervised RT (4x/week, 3 sets using 60-70% of 1-repetition maximum [1-RM]).

RESULTS: AEA (0.5 ng/ml), 2-AG (0.04 ng/ml), dopamine (0.7 ng/ml), and β-endorphin (9.4 pg/ml) concentrations significantly increased in the RS group (P<0.05) while no changes were detected in the RP group. Serotonin (RS = 1.7 ng/mL and RP = 1 ng/mL) concentrations and happiness levels significantly increased in both groups with greater changes in RS group while tryptophan concentrations remained unchanged (P>0.05). In addition, both groups significantly increased muscular endurance with greater changes in RS group (P<0.05).

CONCLUSION: Six weeks of RT combined with saffron supplementation improved AEA, 2-AG, dopamine,β-endorphin, and serotonin concentrations. Moreover, the addition of saffron supplement to chronic RT results in greater improvements in happiness levels than RT alone.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.