The impact of vitamin D on skin aging. - GreenMedInfo Summary
The Impact of Vitamin D on Skin Aging.
Int J Mol Sci. 2021 Aug 23 ;22(16). Epub 2021 Aug 23. PMID: 34445803
Georgeta Bocheva
The active metabolites of vitamin D(D) and lumisterol (L) exert a variety of antiaging and photoprotective effects on the skin. These are achieved through immunomodulation and include anti-inflammatory actions, regulation of keratinocytes proliferation, and differentiation programs to build the epidermal barrier necessary for maintaining skin homeostasis. In addition, they induce antioxidative responses, inhibit DNA damage and induce DNA repair mechanisms to attenuate premature skin aging and cancerogenesis. The mechanism of action would involve interaction with multiple nuclear receptors including VDR, AhR, LXR, reverse agonism on RORα and -γ, and nongenomic actions through 1,25D-MARRS receptor and interaction with the nongenomic binding site of the VDR. Therefore, active forms of vitamin Dincluding its canonical (1,25(OH)D) and noncanonical (CYP11A1-intitated) Dderivatives as well as Lderivatives are promising agents for the prevention, attenuation, or treatment of premature skin aging. They could be administrated orally and/or topically. Other forms of parenteral application of vitamin Dprecursor should be considered to avoid its predominant metabolism to 25(OH)Dthat is not recognized by CYP11A1 enzyme. The efficacy of topically applied vitamin Dand Lderivatives needs further clinical evaluation in future trials.