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Abstract Title:

The influence of PMexposure on non-alcoholic fatty liver disease.

Abstract Source:

Life Sci. 2021 Jan 26 ;270:119135. Epub 2021 Jan 26. PMID: 33513397

Abstract Author(s):

Jiaxin Chen, Lei Wu, Guang Yang, Cong Zhang, Xiaofang Liu, Xiance Sun, Xin Chen, Ningning Wang

Article Affiliation:

Jiaxin Chen

Abstract:

Emerging studies have pointed to a significant relationship between exposure to ambient fine particulate matter (aerodynamic diameter < 2.5 μm, PM2.5) and the incidence of non-alcoholic fatty liver disease (NAFLD). By referring to previous studies on the pathogenesis of NAFLD and PM2.5 exposure-induced metabolic damage, we summarized the possible mediating pathways through which PM2.5 exposure can cause the phenotype and progression of NAFLD. Crucially, PM2.5 exposure is considered to have an impact on the classic hypothesis"multiple hits"of NAFLD. In addition, we also concluded that exposure to PM2.5 can promote the development of NAFLD by destroying the intestinal epithelium and microbiotic homeostasis, triggering endoplasmic reticulum stress, inducing abnormal expression of specific microRNA or inflammatory factors.

Study Type : Human Study

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