Abstract Title:

Systemic Immune Response to Vaccination on FDG-PET/CT.

Abstract Source:

Nucl Med Mol Imaging. 2016 Dec ;50(4):358-361. Epub 2015 Dec 9. PMID: 27994693

Abstract Author(s):

Mark Mingos, Stephanie Howard, Nicholas Giacalone, David Kozono, Heather Jacene

Article Affiliation:

Mark Mingos


A patient with newly diagnosed right lung cancer had transientF-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a left-sided influenza vaccine 2-3 days before the examination. Although inflammatory FDG uptake in ipsilateral axillary nodes is reported, to our knowledge, this is the first report of visualization of the systemic immune response in the spleen related to the influenza vaccination on FDG-PET/CT. The history, splenic uptake and time course on serial FDG-PET/CT helped to avoid a false-positive interpretation for progressing lung cancer and alteration of the radiation therapy plan.

Study Type : Human: Case Report

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