Abstract Title:

Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells.

Abstract Source:

Brain Res. 2016 Jun 30. Epub 2016 Jun 30. PMID: 27373979

Abstract Author(s):

Yao Fei, Yajie Xiong, Yifan Zhao, Wenjuan Wang, Meilin Han, Long Wang, Caihong Tan, Zhongqin Liang

Article Affiliation:

Yao Fei

Abstract:

Curcumin can be used to prevent and treat cancer. However, its exact underlying molecular mechanisms remain poorly understood. Cathepsin L, a lysosomal cysteine protease, is overexpressed in several cancer types. This study aimed to determine the role of cathepsin L in curcumin-mediated inhibition of growth, migration, and invasion of glioma cells. Results revealed that the activity of cathepsin L was enhanced in curcumin-treated glioma cells. Cathepsin L knockdown induced by RNA interference significantly promoted curcumin-induced cytotoxicity, apoptosis, and cell cycle arrest. The knockdown also inhibited the migration and invasion of glioma cells. Our results suggested that the inhibition of cathepsin L can enhance the sensitivity of glioma cells to curcumin. Therefore, cathepsin L may be a new target to enhance the efficacy of curcumin against cancers.

Study Type : In Vitro Study

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