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Abstract Title:

Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2.

Abstract Source:

Food Funct. 2020 Sep 23 ;11(9):7415-7420. PMID: 32966484

Abstract Author(s):

Shuang Song, Haoran Peng, Qingling Wang, Zhengqi Liu, Xiuping Dong, Chengrong Wen, Chunqing Ai, Yujiao Zhang, Zhongfu Wang, Beiwei Zhu

Article Affiliation:

Shuang Song

Abstract:

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the world at an unprecedented rate. In the present study, 4 marine sulfated polysaccharides were screened for their inhibitory activity against SARS-CoV-2, including sea cucumber sulfated polysaccharide (SCSP), fucoidan from brown algae, iota-carrageenan from red algae, and chondroitin sulfate C from sharks (CS). Of them, SCSP, fucoidan, and carrageenan showed significant antiviral activities at concentrations of 3.90-500μg mL-1. SCSP exhibited the strongest inhibitory activity with IC50 of 9.10 μg mL-1. Furthermore, a test using pseudotype virus with S glycoprotein confirmed that SCSP could bind to the S glycoprotein to prevent SARS-CoV-2 host cell entry. The three antiviral polysaccharides could be employed to treat and prevent COVID-19.

Study Type : In Vitro Study

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Sayer Ji
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