Abstract Title:

Inhibitory Effect of Phenolic Acids in Rubus coreanus on Glucosyltransferase of Streptococcus mutans.

Abstract Source:

Curr Microbiol. 2020 Nov ;77(11):3695-3703. Epub 2020 Sep 10. PMID: 32910212

Abstract Author(s):

Youngseok Ham, Tae-Jong Kim

Article Affiliation:

Youngseok Ham


Streptococcus mutans, a typical dental caries-causing oral pathogen, forms dental biofilm by attaching to the surface of teeth. Its glucosyltransferase (GTFase) is responsible for synthesizing water-insoluble glucan from sucrose, which is an important factor for biofilm formation and for providing microbial resistance against stresses. Therefore, inhibiting the activity of GTFase is an effective approach to prevent the formation of dental biofilm even without killing S. mutans. In this study, we found that 2.5 mg/mL of methanol extracts of Camellia sinensis leaf, Diospyros kaki leaf, Nelumbo nucifera seed, Rubus coreanus fruit, and Ulmus davidiana rhizodermis inhibits both GTFase activity and biofilm formation of S. mutans without affecting cell growth. Phenolic acids such as ferulic acid, salicylic acid, and vanillic acid in R. coreanus fruit extract inhibited GTFase activity. Enzyme kinetic analysis shows that ferulic acid, salicylic acid, and vanillic acid are competitive, noncompetitive, and uncompetitive inhibitors, respectively. These results suggest that R. coreanus fruit extracts containing phenolic acids may control and prevent dental caries without killing S. mutans by inhibiting GTFase activity.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.