Inhibitory effects of β-caryophyllene on Helicobacter pylori infection in vitro and in vivo. - GreenMedInfo Summary
Inhibitory Effects ofβ-Caryophyllene onInfection In Vitro and In Vivo.
Int J Mol Sci. 2020 Feb 3 ;21(3). Epub 2020 Feb 3. PMID: 32028744
Hyun Jun Woo
The human specific bacterial pathogen() is associated with severe gastric diseases, including gastric cancer. Recently, the increasing resistance makes the usage of antibiotics less effectively. Therefore, development of a new antimicrobial agent is required to controlinfection. In the current study, the inhibitory effect ofβ-caryophyllene ongrowth, as well as the antibacterial therapeutic effect, has been demonstrated.β-caryophyllene inhibitedgrowth via the downregulation ofE,N,B, andA and also downregulated virulence factors such as CagA, VacA, and SecA proteins.β-caryophyllene inhibited expression of several T4SS components, so that CagA translocation into-infected AGS gastric cancer cells was decreased byβ-caryophyllene treatment. β-caryophyllene also inhibited VacA entry through the downregulation of T5SS. Afterβ-caryophyllene administration on Mongolian gerbils, the immunohistochemistry (IHC) and Hematoxylin&Eosin stains showed therapeutic effects in the treated groups. Hematological data, which was consistent with histological data, support the therapeutic effect ofβ-caryophyllene administration. Such a positive effect of β-caryophyllene oninfection potently substantiates the natural compound as being capable of being used as a new antimicrobial agent or functional health food to help patients who are suffering from gastroduodenal diseases due toinfection.