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Article Publish Status: FREE
Abstract Title:

Inhibitory Effects ofFucoidans Against Noroviruses.

Abstract Source:

Viruses. 2020 09 7 ;12(9). Epub 2020 Sep 7. PMID: 32906822

Abstract Author(s):

Hyojin Kim, Chae Yeon Lim, Dan Bi Lee, Jong Hyeon Seok, Kyung Hyun Kim, Mi Sook Chung

Article Affiliation:

Hyojin Kim

Abstract:

Norovirus is the leading cause of nonbacterial foodborne disease outbreaks. Human noroviruses (HuNoVs) bind to histo-blood group antigens as the host receptor for infection. In this study, the inhibitory effects of fucoidans from brown algae,(LJ),andsporophyll, were evaluated against murine norovirus (MNoV), feline calicivirus (FCV) and HuNoV. Pretreatment of MNoV or FCV with the fucoidans at 1 mg/mL showed high antiviral activities, with 1.1 average log reductions of viral titers in plaque assays. They also showed significant inhibition on the binding of the P domains of HuNoV GII.4 and GII.17 to A- or O-type saliva and the LJ fucoidan was the most effective, reaching 54-72% inhibition at 1 mg/mL. In STAT1mice infected with MNoV, oral administration of the LJ fucoidan, composed of mainly sulfated fucose and minor amounts of glucose and galactose, improved the survival rates of mice and significantly reduced the viral titers in their feces. Overall, these results provide the LJ fucoidan can be used to reduce NoV outbreaks.

Study Type : Animal Study, In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)

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