Article Publish Status: FREE
Abstract Title:

Inhibitory potentials ofoil against aluminium-induced behavioral deficits and neuropathology in rats.

Abstract Source:

Anat Cell Biol. 2020 Sep 30 ;53(3):342-354. PMID: 32839358

Abstract Author(s):

Gbadamosi Ismail Temitayo, Bamisi Olawande, Yawson Olushola Emmanuel, Arogundade Tolulope Timothy, Ogunrinola Kehinde, Lewu Folashade Susan, Lambe Ezra, Olajide Olayemi Joseph

Article Affiliation:

Gbadamosi Ismail Temitayo


is a tropical phytomedicinal plant that is widely known for its hypoglycemic, hypolipidemic, anxiolytic, sedative, antioxidative and anti-inflammatory properties. In this study, we have examined the neuroprotective effects of the essential oil (ESO) of, following aluminum chloride (AlCl)-induced neurotoxicity within the cerebellum of Wistar rats. A total of 40 adult male Wistar rats were assigned into five groups and treated orally as follows: A-phosphate-buffered saline (1 ml daily for 15 days); B-ESO (50 mg/kg daily for 15 days); C-AlCl(100 mg/kg daily for 15 days); D-AlClthen ESO (100 mg/kg AlCldaily for 15 days followed by 50 mg/kg ESO daily for subsequent 15 days); E-ESO then AlCl(50 mg/kg ESO daily for 15 days followed by 100 mg/kg AlCldaily for following 15 days). To address our questions, we observed the locomotion and exploratory behavior of the rats in the open field apparatus and subsequently evaluated cerebellar oxidative redox parameters, neural bioenergetics, acetylcholinesterase levels, transferrin receptor protein, and total protein profiles by biochemical assays. Furthermore, we investigated cerebellar histomorphology and Nissl profile by H&E and Cresyl violet Nissl staining procedures. ESO treatment markedly attenuated deficits in exploratory activities and rearing behavior following AlCltoxicity, indicating its anxiolytic potentials. Additionally, AlClevokedincrease in malondialdehyde and nitric oxide levels, as well as repressed cerebellar catalase, glutathione peroxidase, and superoxide dismutase profiles were normalised to baseline levels by ESO treatment. Treatment with ESO, ergo, exhibits substantial neuroprotective and modulatory potentials in response to AlCltoxicity.

Study Type : Animal Study

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