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Abstract Title:

Innovative strategies to treat skin wounds with mangiferin: fabrication of transfersomes modified with glycols and mucin.

Abstract Source:

Nanomedicine (Lond). 2020 07 ;15(17):1671-1685. Epub 2020 Jul 17. PMID: 32677507

Abstract Author(s):

Mohamad Allaw, Maria Pleguezuelos-Villa, Maria Letizia Manca, Carla Caddeo, Matteo Aroffu, Amparo Nacher, Octavio Diez-Sales, Amparo Ruiz Saurí, Elvira Escribano Ferrer, Anna Maria Fadda, Maria Manconi

Article Affiliation:

Mohamad Allaw

Abstract:

The moisturizing properties of glycerol, the penetration enhancing capability of propylene glycol and the bioadhesive properties of mucin were combined to improve the carrier capabilities of transfersomes and the efficacy of mangiferin in the treatment of skin lesions.Mangiferin was incorporated in transfersomes and glycoltransfersomes, which were also modified with mucin. The physico-chemical features were assessed, along with the efficacy against oxidative stress and skin woundsand.Glycoltransfersomes promoted the deposition of mangiferin in epidermis and dermis, protected fibroblasts from oxidative stress and stimulated their proliferation. The wound healing and anti-inflammatory efficacy of glycoltransfersomes were confirmed.Results confirmed the potential of glycoltransfersomes in preventing/treating of skin lesions.

Study Type : In Vitro Study

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