Insights on cannabidiol's antiallodynic and anxiolytic mechanisms of action in a model of neuropathic pain.
Pain Rep. 2019 Sep-Oct;4(5):e774. Epub 2019 Aug 13. PMID: 32766463
Recent studies have shown that cannabidiol (CBD) could have a great therapeutic potential for treating disorders such as chronic pain and anxiety. In the target article, the authors propose that CBD modulates serotonergic transmission and reverses allodynia and anxiety-like behaviour in a rat model of neuropathic pain. Furthermore, this study shows an antinociceptive effect mediated by TRPVand partially by 5-HTreceptors, as well as an anxiolytic effect mediated by 5-HTreceptors.De Gregorio D, McLaughlin RJ, Posa L, Ochoa-Sanchez R, Enns J, Lopez-Canul M, Aboud M, Maione S, Comai S, and Gobbi G. Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. PAIN 2019;160:36-150.