Abstract Title:

Insulin sensitivity improvement with exercise training is mediated by body weight loss in subjects with metabolic syndrome.

Abstract Source:

Diabetes Metab. 2019 May 31. Epub 2019 May 31. PMID: 31158474

Abstract Author(s):

Ricardo Mora-Rodriguez, Juan Fernando Ortega, Miguel Ramirez-Jimenez, Alfonso Moreno-Cabañas, Felix Morales-Palomo

Article Affiliation:

Ricardo Mora-Rodriguez


AIM: - To determine whether exercise training improves insulin actions through concomitant body weight loss (BWL).

METHODS: - Subjects (aged 55± 8 years) with metabolic syndrome (MetS), prediabetes (fasting blood glucose: 111 ± 2 mg·dL, HbA1c: 5.85± 0.05%) and abdominal obesity (waist circumference: 104 ± 7.9 cm) were randomly allocated to either a group performing aerobic interval training (EXER; n = 76) or a sedentary group receiving lifestyle counselling (CONT; n = 20) for 16 weeks. Results - At baseline, insulin sensitivity (according to HOMA2 and intravenous glucose tolerance test; CS), body composition and VOwere similar between the groups. After the intervention, both groups had similar BWL (1-2%), but only the EXER group showed decreased [mean (95% CI)] trunk fat mass [from 18.2 (17.4-18.9) to 17.3 kg (16.6-17.9); P<0.001] and HOMA2 scores [from 1.6 (1.5-1.7) to 1.4 (1.3-1.5); P = 0.001], and increased VO[from 2.07 (1.92-2.21) to 2.28 (2.11-2.45) LO·min; P<0.001]. However, CSdid not improve in any group. Within-group subdivision by BWL (≤ 0%, 0-3%, ≥ 3%) revealed higher CSin those with BWL≥ 3% in both groups. Trunk fat mass reductions were closely associated with CSand HOMA-IR improvement (r = -0.452-0.349; P<0.001).

CONCLUSION: - In obese MetS subjects with prediabetes, 3% BWL is required for consistent improvement in insulin sensitivity. Thus, exercise-training programmes should be combined with calorie restriction to achieve BWL levels that prevent the development of diabetes.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.