Abstract Title:

Skin rejuvenation using intense pulsed light: a randomized controlled split-face trial with blinded response evaluation.

Abstract Source:

Arch Dermatol. 2006 Aug;142(8):985-90. PMID: 16924047

Abstract Author(s):

Lene Hedelund, Eva Due, Peter Bjerring, Hans Christian Wulf, Merete Haedersdal

Article Affiliation:

Department of Dermatology, University of Copenhagen and Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark. [email protected]


OBJECTIVE: To evaluate efficacy and adverse effects of intense pulsed light rejuvenation in a homogeneous group of patients.

DESIGN: Randomized controlled split-face trial.

SETTING: University dermatology department.

PATIENTS: Thirty-two female volunteers with Fitzpatrick skin type I through III and class I or II rhytids.

INTERVENTIONS: Subjects were randomized to 3 intense pulsed light treatments at 1-month intervals or to no treatment of right or left sides of the face.

MAIN OUTCOME MEASURES: Primary end points were skin texture and rhytids. Secondary end points were telangiectasia, irregular pigmentation, and adverse effects. Efficacy was evaluated by patient self-assessments and by blinded clinical and photographic evaluations up to 9 months after final treatment. Adverse effects were assessed clinically and by noninvasive skin reflectance measurements.

RESULTS: Skin texture was significantly improved at all clinical assessments except at the 6-month examination (P<.006). The improvements peaked at 1 month after treatment, at which time 23 (82%) of 28 patients had better appearances of treated vs untreated sides. Most patients obtained mild or moderate improvements, and 16 patients (58%) self-reported mild or moderate efficacy on skin texture. Rhytids were not significantly different on treated vs untreated sides, and 19 patients (68%) reported uncertain or no efficacy on rhytids. Significant improvements of telangiectasia (P<.001) and irregular pigmentation (P<.03) were found at all assessments. Three patients withdrew from the study because of pain related to treatment.

CONCLUSIONS: Three intense pulsed light treatments improved skin texture, telangiectasia, and irregular pigmentation but had no efficacy on rhytids. Adverse events were minimal, but included scar in 1 patient.

Study Type : Human Study

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