Abstract Title:

Intravenous Vitamin C as Ancillary Treatment for Cranial Polyneuritis and Meningitis due to Varicella Zoster Virus Reactivation.

Abstract Source:

Acta Med Okayama. 2020 Jun ;74(3):257-260. PMID: 32577025

Abstract Author(s):

Takashi Hongo, Fusao Ikeda, Shinichi Fujioka, Riku Akatsuka, Tosifumi Fujiwara, Kazuhide Yamamoto

Article Affiliation:

Takashi Hongo


A 65-year-old Japanese woman developed vesicular eruptions on her right ear due to varicella zoster virus (VZV) reactivation, followed by cranial polyneuritis and meningitis affecting her right cranial nerves V, VII, VIII, IX, and X. After acyclovir administration, her facial paralysis worsened. Intravenous methylprednisolone and vitamin C were administered on Day 4 post-admission. Her symptoms steadily improved, and by Day 45 she had fully recovered. Cranial polyneuritis is a rare complication of VZV reactivation, and there is no established method of treatment. This is the first report of full recovery from cranial polyneuritis using intravenous vitamin C as ancillary treatment.

Study Type : Human: Case Report
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)
Additional Keywords : Virus Reactivation

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