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Abstract Title:

Iron modulatory property of a polysaccharide from Indian medicinal plant.

Abstract Source:

Free Radic Res. 2021 Jan 6:1-10. Epub 2021 Jan 6. PMID: 33327808

Abstract Author(s):

Mahesh Subramanian, Gajanan J Chintalwar, Subrata Chattopadhyay

Article Affiliation:

Mahesh Subramanian

Abstract:

Despite being an essential element for normal functioning of cells and organisms, iron, in excess, can induce oxidative stress by generating reactive oxygen species. A water-soluble, non-toxic iron chelator can reduce the iron-induced oxidative stress in the body as well as help in extricating excess iron. Herein, we report an-derived antioxidant polysaccharide (OSP) that inhibits the deleterious effect of iron.is a widely acknowledged medicinal plant contributing toward several biological benefits. Besides showing good hydroxyl radical scavenging activity, OSP could bind to ferric and ferrous ions to prevent their participation in redox reactions as revealed from modified 2-deoxyribose assays, carried out under various conditions. It also acted as an iron modulator to prevent site-specific damage and was effective in protecting mouse fibroblast L929 cells against iron induced death.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-Apoptotic : CK(2905) : AC(1672)

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