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Article Publish Status: FREE
Abstract Title:

Extract Ameliorates the Hyperglycemia and Body Weight Gain ofMice through Regulation of the PI3K/Akt Pathway and Thermogenic Factors by FGF21.

Abstract Source:

Mar Drugs. 2019 Jul 9 ;17(7). Epub 2019 Jul 9. PMID: 31323977

Abstract Author(s):

Young-Jin Seo, Kippeum Lee, Sungwoo Chei, You-Jin Jeon, Boo-Yong Lee

Article Affiliation:

Young-Jin Seo

Abstract:

Type 2 diabetes mellitus and related metabolic disorders, such as dyslipidemia, present increasing challenges to health worldwide, as a result of urbanization, the increasing prevalence of obesity, poor lifestyle, and other stress-related factors.extract (IOE) is known to be effective at lowering blood glucose and ameliorating metabolic disease. However, detailed mechanisms for these effects have yet to be elucidated. Here, we show that IOE ameliorates substrate (IRS)/ phosphatidylinositol 3-kinase (PI3K)/Akt pathway and increasing glucose transporter 4 (GLUT4) expression in skeletal muscle and white adipose tissue (WAT). We also demonstrate that IOE increases the expression of fibroblast growth factor (FGF)21, a regulator of glucose and energy metabolism in muscle and WAT. In addition, IOE administration increased peroxisome proliferator-activated receptorγ coactivator 1α expression, which regulates expression of the key thermogenic molecule uncoupling protein 1 in WAT. Thus, the effects of IOE to ameliorate hyperglycemia and adiposity may be mediated through FGF21 activating insulin signaling and increasing the expression of GLUT4 and pro-thermogenic factors.

Study Type : Animal Study

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