An isoflavonoid from seeds of Lepidium sativum L. has a protective effect on hepatotoxicity induced by paracetamol. - GreenMedInfo Summary

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Abstract Title:

A new isoflavonoid from seeds of Lepidium sativum L. and its protective effect on hepatotoxicity induced by paracetamol in male rats.

Abstract Source:

Molecules. 2014 ;19(10):15440-51. Epub 2014 Sep 26. PMID: 25264831

Abstract Author(s):

Mohamed Sakran, Yasser Selim, Nahla Zidan

Article Affiliation:

Mohamed Sakran

Abstract:

A new isoflavonoid, 5,6-dimethoxy-2',3'-methylenedioxy-7-C-β-d-gluco-pyranosyl isoflavone was isolated from the seeds of Lepidium sativum L. along with two known isoflavonoids, 7-hydroxy-4',5,6-trimethoxyisoflavone and 7-hydroxy-5,6-dimethoxy-2',3'-methylenedioxyisoflavone. The structures of all compounds were elucidated with NMR spectrometry. Compounds 1,2 and the new isoflavonoid 3 were evaluated for their ability to reduce the hepatotoxicity induced by paracetamol in male rats by reducing the damage and toxicity effects on liver cells with a significant improvement of total antioxidant capacity, normalizing the levels of liver enzymes GSH, SOD, GPX, CAT and GST compared to control group.

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Garden Cress (Lepidium sativum) : CK(56) : AC(26)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(654) : AC(337), Chemically-Induced Liver Damage : CK(1565) : AC(1010), Oxidative Stress : CK(9437) : AC(5037)

Pharmacological Actions : Antioxidants : CK(21528) : AC(13231), Hepatoprotective : CK(5098) : AC(3517)

Additional Keywords : Plant Extracts : CK(17959) : AC(6472)

Problem Substances : Acetaminophen, Paracetamol : CK(839) : AC(284)