Abstract Title:

Anxiolytic-like effects of kava-kava in the elevated plus maze test--a comparison with diazepam.

Abstract Source:

Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jun;26(5):855-60. PMID: 12369257

Abstract Author(s):

André Rex, Eve Morgenstern, Heidrun Fink

Article Affiliation:

Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität, Kosertr. 20, D-14195 Berlin, Germany. [email protected]


Kava-Kava, a drug derived from a traditional psychoactive beverage used in the South Pacific, is known for tranquilizing and anxiolytic effects. Extracts made from the roots of the Kava plant (Piper methysticum G. Forster) have anxiolytic and mild sedative effects in man. To our knowledge, there are only few data concerning the efficacy of Kava-Kava in animal tests of anxiety. This study was carried out to compare the anxiolytic potential of Kava-Kava extract LI 150 with diazepam. Acute effects of diazepam and a Kava-Kava preparation, compared to their respective controls, were examined in Wistar rats using the elevated plus maze (X-maze). The time spent on open arms, the percentage of open-arm visits and parameters describing the risk assessment were evaluated. LI 150 (120-240 mg/kg p.o.) affected the behaviour measured in the X-maze test, inducing an anxiolytic like behaviour similar to diazepam (15 mg/kg p.o.). These data support the use of Kava-Kava in the treatment of anxiety.

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.