Abstract Title:

Kefir prevented excess fat accumulation in diet-induced obese mice.

Abstract Source:

Biosci Biotechnol Biochem. 2017 May ;81(5):958-965. Epub 2017 Jan 23. PMID: 28110622

Abstract Author(s):

Jae-Woo Choi, Hye Won Kang, Won-Chul Lim, Mi-Kyoung Kim, In-Young Lee, Hong-Yon Cho

Article Affiliation:

Jae-Woo Choi


Excessive body fat accumulation can result in obesity, which is a serious health concern. Kefir, a probiotic, has recently shown possible health benefits in fighting obesity. This study investigated the inhibitory effects of 0.1 and 0.2% kefir powder on fat accumulation in adipose and liver tissues of high-fat diet (HFD)-induced obese mice. Kefir reduced body weight and epididymal fat pad weight and decreased adipocyte diameters in HFD-induced obese mice. This was supported by decreased expression of genes related to adipogenesis and lipogenesis as well as reduced proinflammatory marker levels in epididymal fat. Along with reduced hepatic triacylglycerol concentrations and serum alanine transaminase and aspartate transaminase activities, genes related to lipogenesis and fatty acid oxidation were downregulated and upregulated, respectively, in liver tissue. Kefir also decreased serum triacylglycerol, total cholesterol, and low-density lipoprotein-cholesterol concentrations. Overall, kefir has the potential to prevent obesity.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Hypolipidemic : CK(5358) : AC(1221)

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