Article Publish Status: FREE
Abstract Title:

Korean Red Ginseng extract ameliorates melanogenesis in humans and induces antiphotoaging effects in ultraviolet B-irradiated hairless mice.

Abstract Source:

J Ginseng Res. 2020 May ;44(3):496-505. Epub 2019 May 15. PMID: 32372872

Abstract Author(s):

Evelyn Saba, Seung-Hyung Kim, Yuan Yee Lee, Chae-Kyu Park, Jae-Wook Oh, Tae-Hwan Kim, Hyun-Kyoung Kim, Seong-Soo Roh, Man Hee Rhee

Article Affiliation:

Evelyn Saba


Background: is a marvelous herbal remedy for all ailments of body. That may be why it is called Panax, which means"cure for all". Melanin is a pigment that gives color to our skin; however, increased melanin production can lead to tumor formation. Human exposure to ultraviolet B radiation has increased extensively owing to the increased sunlight due to global warming. Consequently, a phenomenon called photoaging has been observed for all skin colors and types. As a result of this phenomenon, a set of enzymes called matrix metalloproteinases, which serve as degradation enzymes for extracellular matrix proteins, mainly collagen, is increased, causing depletion of collagen and resulting in early wrinkle formation.

Methods: Therefore, in our study, we used the murine melanoma cell line B16/F10 to study the inhibition of melanogenesis by Korean Red Ginseng (KRG) extractand HRM-2 hairless mice exposed to artificial ultraviolet B to examine the efficacy of KRG. We prepared a 3% red ginseng extract cream and evaluated its effects on human skin.

Results: Our results demonstrated that KRG induced potent suppression of tyrosinase activity and melanin production in B16/F10 cells; moreover, it reduced the transcription and translation of components involved in the melanin production pathway. In theexperiments, KRG potently suppressed the expression of matrix metalloproteinases, reduced wrinkle formation, and inhibited collagen degradation. On human skin, ginseng cream increased skin resilience and skin moisture and enhanced skin tone.

Conclusion: Therefore, we conclude that KRG is an excellent skin whitening and antiaging product.

Study Type : Animal Study

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