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Article Publish Status: FREE
Abstract Title:

Korean Red Ginseng extract treatment prevents post-antibiotic dysbiosis-induced bone loss in mice.

Abstract Source:

J Ginseng Res. 2023 Mar ;47(2):265-273. Epub 2022 Aug 31. PMID: 36926616

Abstract Author(s):

Ho Jun Kang, Nicholas Chargo, Soumya Chennupati, Kerri Neugebauer, Jae Youl Cho, Robert Quinn, Laura R McCabe, Narayanan Parameswaran

Article Affiliation:

Ho Jun Kang

Abstract:

BACKGROUND: The intestinal microbiota is an important regulator of bone health. In previous studies we have shown that intestinal microbiota dysbiosis, induced by treatment with broad spectrum antibiotics (ABX) followed by natural repopulation, results in gut barrier dysfunction and bone loss. We have also shown that treatment with probiotics or a gut barrier enhancer can inhibit dysbiosis-induced bone loss. The overall goal of this project was to test the effect of Korean Red Ginseng (KRG) extract on bone and gut health using antibiotics (ABX) dysbiosis-induced bone loss model in mice.

METHODS: Adult male mice (Balb/C, 12-week old) were administered broad spectrum antibiotics (ampicillin and neomycin) for 2 weeks followed by 4 weeks of natural repopulation. During this 4-week period, mice were treated with vehicle (water) or KRG extract. Other controls included mice that did not receive either antibiotics or KRG extract and mice that received only KRG extract. At the end of the experiments, we assessed various parameters to assess bone, microbiota andintestinal permeability.

RESULTS: Consistent with our previous results, post-ABX- dysbiosis led to significant bone loss. Importantly, this was associated with a decrease in gut microbiota alpha diversity and an increase in intestinal permeability. All these effects including bone loss were prevented by KRG extract treatment. Furthermore, our studies identified multiple genera includingandas well asto be potentially linked to the effect of KRG extract on gut-bone axis.

CONCLUSION: Together, our results demonstrate that KRG extract regulates the gut-bone axis and is effective at preventing dysbiosis-induced bone loss in mice.

Study Type : Animal Study

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