Abstract Title:

Effect of Mitragyna speciosa aqueous extract on ethanol withdrawal symptoms in mice.

Abstract Source:

Fitoterapia. 2007 Apr;78(3):182-5. Epub 2007 Feb 6. PMID: 17335995

Abstract Author(s):

Ekkasit Kumarnsit, Niwat Keawpradub, Watcharin Nuankaew


Administration of the aqueous extract of Mitragyna speciosa at a dose of 300 mg/kg significantly inhibited ethanol withdrawal-induced behaviors that included rearing, displacement and head weaving. The results also showed that at doses of 100, 300 and 500 mg/kg M. speciosa showed antidepressant activity without effect on the spontaneous motor activity.

Study Type : Animal Study
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