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Article Publish Status: FREE
Abstract Title:

Krill Oil Combined with subsp.F1-7 Alleviates the Atherosclerosis of ApoEMice.

Abstract Source:

Foods. 2021 Oct 6 ;10(10). Epub 2021 Oct 6. PMID: 34681423

Abstract Author(s):

Xi Liang, Zhe Zhang, Youyou Lv, Haiyan Lu, Tongjie Liu, Huaxi Yi, Maozhen Zhao, Lanwei Zhang, Pimin Gong

Article Affiliation:

Xi Liang

Abstract:

There has been an increasing number of studies on the interaction between active substances and probiotics to improve disease. Both krill oil (KO) and probiotics have the effect of improving atherosclerotic cardiovascular disease, but the combined effect has not been explored. Therefore, the purpose of this study was to explore the improvement effect of KO combined with probiotics on atherosclerosis. The atherosclerotic plaque area of ApoEmice was detected after the intervention of KO,subsp.F1-7 (F1-7), and KO combined withF1-7. The results showed thatF1-7, KO, and KO combined withF1-7 could significantly reduce the area of atherosclerotic plaque and improve the levels of serum lipids and inflammatory factors. They could regulate the farnesoid X receptor (FXR)/cholesterol 7-alpha hydroxylase (CYP7A1) pathway to reduce lipid accumulation. The intervention groups could also improve the inflammatory response by downregulating the Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) pathway. The anti-inflammatory effect of the interaction group was significantly better than that of KO. It proved thatF1-7 might play a synergistic effect in the improvement of inflammation by KO to the alleviation of atherosclerosis.

Study Type : Animal Study

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