Abstract Title:

A pilot study of L-arginine supplementation on functional capacity in peripheral arterial disease.

Abstract Source:

Vasc Med. 2005 Nov;10(4):265-74. PMID: 16444855

Abstract Author(s):

Roberta K Oka, Andrzej Szuba, John C Giacomini, John P Cooke


Peripheral arterial disease (PAD) impairs walking capacity and is often associated with a profound endothelial vasodilator dysfunction, characterized by reduced bioactivity and/or synthesis of endothelium-derived nitric oxide (NO). Previous studies have suggested that dietary supplementation of L-arginine, the precursor of NO, improves endothelium-dependent vasodilation, limb blood flow and walking distance. However, these studies have been small, and have used large intravenous doses of L-arginine. The optimal dose of L-arginine has not been determined. Accordingly, this pilot study was conducted to establish the lowest effective oral dose of L-arginine to improve walking distance in preparation for the definitive study. Patients with PAD and intermittent claudication (n = 80) participated in this study. Eligibility criteria included: (1) ankle-brachial index (ABI) at restor = 25%; and (3) difference in absolute claudication distance of

Study Type : Human Study

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