Abstract Title:

l-Arginine supplementation protects against hepatic ischemia-reperfusion lesions in rabbits.

Abstract Source:

Transplant Proc. 2009 Apr;41(3):816-9. PMID: 19376360

Abstract Author(s):

M O Taha, M J Simões, M A Haddad, R C Capelato, N Budny, A H Matsumoto, P C M Soares, W M Santos, G D Armeato, C M Araki, J S M Gomes, K G Magalhães, I L S Tersariol, H P Monteiro, I S Oliveira-Júnior, I Oliveira, A Jurkiewicz, A Caricati-Neto

Article Affiliation:

Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil. taha@uol.com.br

Abstract:

We evaluated the effects of a substrate in the biosynthesis of nitric oxide (NO)-l-arginine (LARG)-on hepatic lesions caused by ischemia/reperfusion (I/R) injury in rabbit livers. Rabbits were pretreated with LARG (150 mg/kg IV) or saline solution 0.9% (SS) before the hepatic I/R procedure. The effects of LARG on hepatic injury were evaluated before and after I/R. The warm hepatic I/R procedure produced profound acute liver injury, as indicated by elevated values of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactic dehydrogenase (LDH), as well as a high apoptotic cell count. All changes were attenuated by treatment with LARG before the hepatic I/R procedure. These results suggested that LARG produced protective effects on hepatic I/R lesions. This protective effect of LARG was probably associated with blocking generation of superoxide anions during the hepatic I/R procedure.

Study Type : Animal Study

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