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Article Publish Status: FREE
Abstract Title:

A Pilot Study of the Effect ofObtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers.

Abstract Source:

Nutrients. 2021 Oct 29 ;13(11). Epub 2021 Oct 29. PMID: 34836153

Abstract Author(s):

Li-Hua Mei, Wen-Xuan Zheng, Zheng-Tao Zhao, Ning Meng, Qin-Ren Zhang, Wen-Jun Zhu, Rui-Ding Li, Xiao-Lin Liang, Quan-Yang Li

Article Affiliation:

Li-Hua Mei

Abstract:

Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbiota in twenty healthy, young volunteers. Volunteers were randomly divided into equal probiotic and placebo groups and changes in blood biochemical indicators, oxidative and inflammatory markers, and gut microbiota were examined after three weeks of probiotic intervention. The probiotic group's antioxidant levels were significantly enhanced post-intervention. Total antioxidant capacity (T-AOC) levels were significantly increased (<0.0001), while malondialdehyde (MDA) levels decreased (<0.05), and total superoxide dismutase (T-SOD) levels increased, but with no significant difference. In addition, Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) levels were significantly up-regulated and down-regulated (<0.05, respectively).,, andexpression was significantly reduced (<0.05), while,, andexpression increased (<0.05). Volunteer health status was quantified using principal components and cluster analysis, indicating that the probiotic group's overall score was higher than that of the placebo group. The results of this pilot study suggestLTL 1879 can significantly improve specific immune, oxidative, and gut microbiota characteristics related to health factors.

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