Article Publish Status: FREE
Abstract Title:

Effects of Lawsonia inermis L. (Henna) leaves' methanolic extract on carbon tetrachloride-induced hepatotoxicity in rats.

Abstract Source:

J Intercult Ethnopharmacol. 2016 Jan-Feb;5(1):22-6. Epub 2015 Dec 22. PMID: 27069719

Abstract Author(s):

Musab Awad Mohamed, Imad Mohamed Taj Eldin, Abd-Elwahab Hassan Mohammed, Hozeifa Mohamed Hassan

Article Affiliation:

Musab Awad Mohamed


BACKGROUND: Natural products with therapeutic properties such as plants, minerals, and animal products, for many years, were the main sources of drugs for the treatment of numerous diseases; hence selection of Lawsonia inermis L. (Henna) to study its hepatoprotective activity was considered.

OBJECTIVES: This was an attempt to evaluate the hepatoprotective effect of L. inermis leaves' methanolic extract on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats.

MATERIALS AND METHODS: The L. inermis leaves' methanolic extract, which obtained by maceration, was orally administered in doses of 100 mg/kg and 200 mg/kg to the tested animals to assess its effects on serum levels of hepatotoxicity parameters, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin, and total proteins along with histopathological liver sections examination, while silymarin (25 mg/kg), a potent hepatoprotective drug, was used as standard control.

RESULTS: The two doses of the plant extract showed dose-dependent hepatoprotective effect, as evident by the significant reduction (P<0.05) in serum levels of AST, ALT, ALP, and bilirubin along with the improvement in histopathological liver sections compared to CCl4-only treated animals.

CONCLUSION: As experimentally evident, it could be concluded that this plant material could provide a hepatoprotective effect that could be attributed to its antioxidant properties.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.