L. kefiranofaciens DD2 effectively and directly inhibits S. mutans and S. sobrinus. - GreenMedInfo Summary

:andare major causative bacterial pathogens of dental caries.: We investigated the applicability of threestrains (DD2, DD5, and DD6) isolated from kefir and three commercialstrains (ATCC 10,012,JCM 1022, andATCC 7469) as potential oral probiotics with respect to their survivability in an experimental oral environment, antimicrobial activity, and anti-biofilm formation activity againstand.: Strains DD2, ATCC 10012, ATCC 7469, and JCM 1022 had the best oral survivability, including aerotolerance and enzymatic resistance, and inhibited the growth and biofilm formation ofand. In particular, DD2 suppressed all three classes of biofilm formation-associated genes: those associated with carbohydrate metabolism and those encoding regulatory biofilm and adhesion proteins.: These results indicate that the novel kefir isolateDD2 effectively and directly inhibitsand.