Lactobacillus and Bifidobacterium Improved Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota.
Mol Nutr Food Res. 2019 Aug 21:e1900603. Epub 2019 Aug 21. PMID: 31433910
SCOPE: Age-related degeneration is associated with imbalances of gut microbiota and its related immune system, thereby gut microbiota dysbiosis is considered to be a key target to improve senescence. The potential roles of probiotics on physiological function and cognitive ability in aged mice were investigated in this study.
METHODS AND RESULTS: Lactobacillus casei LC122 or Bifidobacterium longum BL986, were orally administrated for 12 weeks, and the anti-aging effects, as well as the composition and function of gut microbiota were investigated in aged mice. Probiotics supplementation ameliorated hepatic lipid accumulation, enhanced muscle strength and function, attenuated oxidative stress and inflammation in peripheral tissues and improved gut barrier function. These results were associated with improved learning and memory ability as assessed by behavioral tests and up-regulation of neurodegenerative and neurotrophic factors expressions in hippocampus. Moreover, the diversity and composition of gut microbiota were altered in aged mice, and both probiotics treatment displayed distinguished features of gut microbiota. Comparisons of two probiotic strains revealed significant differences in the taxa at family and genus level, leading to the functional profile change of the microbial community.
CONCLUSION: Lactobacillus casei LC122 and Bifidobacterium longum BL986 might be used as novel and promising anti-aging agent in human. This article is protected by copyright. All rights reserved.