Article Publish Status: FREE
Abstract Title:

Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity.

Abstract Source:

Exp Mol Med. 2020 09 ;52(9):1574-1586. Epub 2020 Sep 11. PMID: 32917958

Abstract Author(s):

Youngmin Yoon, Gihyeon Kim, Myung-Giun Noh, Jeong-Hyeon Park, Mongjoo Jang, Sungsoon Fang, Hansoo Park

Article Affiliation:

Youngmin Yoon


The gut microbiota has pivotal roles in metabolic homeostasis and modulation of the intestinal environment. Notably, the administration of Lactobacillus spp. ameliorates diet-induced obesity in humans and mice. However, the mechanisms through which Lactobacillus spp. control host metabolic homeostasis remain unclear. Accordingly, in this study, we evaluated the physiological roles of Lactobacillus fermentum in controlling metabolic homeostasis in diet-induced obesity. Our results demonstrated that L. fermentum-potentiated oxidative phosphorylation in adipose tissue, resulting in increased energy expenditure to protect against diet-induced obesity. Indeed, oral administration of L. fermentum LM1016 markedly ameliorated glucose clearance and fatty liver in high-fat diet-fed mice. Moreover, administration of L. fermentum LM1016 markedly decreased inflammation and increased oxidative phosphorylation in gonadal white adipose tissue, as demonstrated by transcriptome analysis. Finally, metabolome analysis showed that metabolites derived from L. fermentum LM1016-attenuated adipocyte differentiation and inflammation in 3T3-L1 preadipocytes. These pronounced metabolic improvements suggested that the application of L. fermentum LM1016 could have clinical applications for the treatment of metabolic syndromes, such as diet-induced obesity.

Study Type : Animal Study

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