Article Publish Status: FREE
Abstract Title:

Suppresses the Production of Proinflammatory Cytokines in-Infected Macrophages by Inhibiting the Expression of ADAM17.

Abstract Source:

Front Immunol. 2019 ;10:2326. Epub 2019 Oct 4. PMID: 31636639

Abstract Author(s):

Hanna G Gebremariam, Khaleda Rahman Qazi, Tanvi Somiah, Sushil Kumar Pathak, Hong Sjölinder, Eva Sverremark Ekström, Ann-Beth Jonsson

Article Affiliation:

Hanna G Gebremariam


The ability ofto evade the host immune system allows the bacterium to colonize the host for a lifetime. Long-term infection withcauses chronic inflammation, which is the major risk factor for the development of gastric ulcers and gastric cancer. Lactobacilli are part of the human microbiota and have been studied as an adjunct treatment ineradication therapy. However, the molecular mechanisms by which lactobacilli act againstinfection have not been fully characterized. In this study, we investigated the anti-inflammatory effects ofstrains upon coincubation of host macrophages with. We found thatKx110A1 (L. gas), a strain isolated from a human stomach, but not other testedspecies, blocked the production of the proinflammatory cytokines TNF and IL-6 in-infected macrophages. Interestingly, L. gas also inhibited the release of these cytokines in LPS or LTA stimulated macrophages, demonstrating a general anti-inflammatory property. The inhibition of these cytokines did not occur through the polarization of macrophages from the M1 (proinflammatory) to M2 (anti-inflammatory) phenotype or through the altered viability ofor host cells. Instead, we show that L. gas suppressed the release of TNF and IL-6 by reducing the expression of ADAM17 (also known as TNF-alpha-converting enzyme, TACE) on host cells. Our findings reveal a novel mechanism by which L. gas prevents the production of the proinflammatory cytokines TNF and IL-6 in host macrophages.

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