Abstract Title:

Lactobacillus paracasei subsp. paracasei LC01 positively modulates intestinal microflora in healthy young adults.

Abstract Source:

J Microbiol. 2013 Dec ;51(6):777-82. Epub 2013 Dec 19. PMID: 24385355

Abstract Author(s):

Hao Zhang, Jing Sun, Xianting Liu, Chuan Hong, Yuanbo Zhu, Aiping Liu, Siqi Li, Huiyuan Guo, Fazheng Ren

Article Affiliation:

Hao Zhang


Lactobacillus paracasei subsp. paracasei LC01 (LC01) can tolerate intestinal stresses and has antioxidant activity. To evaluate the effect of the bacterium on human intestinal microflora, a randomized, double-blind, placebo-controlled human trial was carried out. Fifty-two healthy adult volunteers were randomized equally to two groups. One group consumed 12% (wt/vol) skimmed milk supplemented with 10(10) CFU of LC01 each day for the 4-week treatment period, and then consumed placebo in the next treatment period, separated by a 2-week washout. The other group followed the reverse order. Group-specific real-time PCR and biochemical analyses was used to determine the intestinal bacterial composition of fecal samples collected at the end of every period, and the concentration of short-chain fatty acids and ammonia. A significant inhibition in fecal Escherichia coli and increase in Lactobacillus, Bifidobacterium, and Roseburia intestinalis were observed after consumption of LC01. Acetic acid and butyric acid were significantly higher in the probiotic stage and fecal ammonia was significantly lower. The results indicated a modulation effect of LC01 on the intestinal microflora of young adults, suggesting a beneficial effect on bowel health. LC01 may have potential value as a probiotic.

Study Type : Human Study
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