Lactobacillus plantarum DP189 prevents cognitive dysfunction in D-galactose/AlCl 3 induced mouse model of Alzheimer's disease. - GreenMedInfo Summary

Probiotic intervention has beneficial effects on host brain function and behavior via regulating microbiota-gut-brain axis; however, the underlying mechanism is not yet understood. Herein, we investigated that the effects ofDP189 (DP189) administration in preventing cognitive dysfunction and pathology of Alzheimer's disease (AD) in D-galactose (D-gal) and AlCl-induced AD model mice. AfterDP189 intervention for 10 weeks, we assessed cognitive behavior, neurotransmitter expression, histological changes, microbial communities, and the mechanisms underlying the disease in AD model mice. The results showed thatDP189 intervention prevented cognitive dysfunction by behavioral test. Increased levels of serotonin, dopamine, and gamma-aminobutyric acid positively affected the pathological processes by ameliorating neuronal damage, beta-amyloid deposition, and tau pathology.DP189 intervention simultaneously modulated the gut microbial communities to alleviate gut dysbiosis. Moreover,.DP189 inhibited tau hyperphosphorylation by regulating the PI3 K/Akt/GSK-3β pathway. These findings indicated that L.DP189 intervention is a promising therapeutic strategy to prevent the onset and development of AD.