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Article Publish Status: FREE
Abstract Title:

HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice.

Abstract Source:

Int J Mol Sci. 2021 Sep 16 ;22(18). Epub 2021 Sep 16. PMID: 34576187

Abstract Author(s):

Kippeum Lee, Jisoo Kim, Soo-Dong Park, Jae-Jung Shim, Jung-Lyoul Lee

Article Affiliation:

Kippeum Lee

Abstract:

Sarcopenia is a loss of muscle mass and function in elderly people and can lead to physical frailty and fall-related injuries. Sarcopenia is an inevitable event of the aging process that substantially impacts a person's quality of life. Recent studies to improve muscle function through the intake of various functional food materials are attracting attention. However, it is not yet known whether probiotics can improve muscle mass and muscle strength and affect physical performance.HY7715 (HY7715) is a lactic acid bacteria isolated from kimchi. The present research shows thatHY7715 increases physical performance and skeletal muscle mass in 80-week-old aged Balb/c male mice. HY7715 not only induces myoblast differentiation and mitochondrial biogenesis but also inhibits the sarcopenic process in skeletal muscle. In addition, HY7715 recovers the microbiome composition and beta-diversity shift. Therefore, HY7715 has promise as a functional probiotic supplement to improve the degeneration of muscle function that is associated with aging.

Study Type : Animal Study

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