Abstract Title:

NK3 andNK49 Alleviate Bacterial Vaginosis and Osteoporosis in Mice by Suppressing NF-B-Linked TNF-Expression.

Abstract Source:

J Med Food. 2019 Oct ;22(10):1022-1031. Epub 2019 Aug 5. PMID: 31381476

Abstract Author(s):

Da-Eun Kim, Jeon-Kyung Kim, Sang-Kap Han, Se-Eun Jang, Myung Joo Han, Dong-Hyun Kim

Article Affiliation:

Da-Eun Kim


Excessive expression of TNF-worsens bacterial vaginosis (BV) and osteoporosis. Therefore, to understand whether probiotics could alleviate vaginosis and osteoporosis, we isolated anti-inflammatoryNK3 andNK49 from kimchi and human fecal lactic acid bacteria collection and examined their effects on(GV)-induced vaginosis and ovariectomy-induced osteoporosis in female mice. Oral gavage of NK3 and/or NK49 significantly alleviated GV-induced vaginosis; these inhibited NF-B activation and TNF-expression in the vagina and uterus, and decreased the GV population in the vagina. Furthermore, treatment with NK3 and/or NK49 alleviated ovariectomy-induced osteoporosis and obesity; these increased blood calcium, phosphorus, and osteocalcin levels and suppressed body weight. GV-induced vaginosis and ovariectomy increased colonic myeloperoxidase activity, TNF-expression, and fecal Proteobacteria population. NK3 and/or NK49 treatments reduced TNF-expression and NF-B activation in the colon. NK3 and NK49 treatment also restored GV- or ovariectomy-disrupted gut microbiota composition. In conclusion, NK3 and NK49 may simultaneously alleviate BV and osteoporosis by suppressing NF-B-linked TNF-expression through the regulation of gut microbiota population.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.