Article Publish Status: FREE
Abstract Title:

V3401 Reduces Inflammatory Biomarkers and Modifies the Gastrointestinal Microbiome in Adults with Metabolic Syndrome: The PROSIR Study.

Abstract Source:

Nutrients. 2019 Jul 31 ;11(8). Epub 2019 Jul 31. PMID: 31370223

Abstract Author(s):

Carmen Tenorio-Jiménez, María José Martínez-Ramírez, Isabel Del Castillo-Codes, Carmen Arraiza-Irigoyen, Mercedes Tercero-Lozano, José Camacho, Natalia Chueca, Federico García, Josune Olza, Julio Plaza-Díaz, Luis Fontana, Mónica Olivares, Ángel Gil, Carolina Gómez-Llorente

Article Affiliation:

Carmen Tenorio-Jiménez


: Previous studies have reported that probiotics may improve clinical and inflammatory parameters in patients with obesity and metabolic syndrome (MetS).V3401 has shown promising results on the components of MetS in animal studies. We aimed to evaluate the effects ofV3401 together with healthy lifestyle recommendations on adult patients with MetS.

METHODS: We carried out a randomized, crossover, placebo-controlled, single-center trial in which we included 53 adult patients newly diagnosed with MetS. Patients were block randomly allocated by body mass index (BMI) and sex to receive a capsule containing either the probioticV3401 (5× 10colony-forming units) or a placebo once daily for 12 weeks. Anthropometric variables, biochemical and inflammatory biomarkers, as well as the gastrointestinal microbiome composition were determined.

RESULTS: There were no differences between groups in the clinical characteristics of MetS. However, we found that interleukin-6 (IL-6) and soluble vascular cell adhesion molecule 1 (sVCAM-1) diminished by effect of the treatment withV3401. Analysis of the gastrointestinal microbiome revealed a rise in the proportion of.

CONCLUSIONS: Consumption ofV3401 improved selected inflammatory parameters and modified the gastrointestinal microbiome. Further studies are needed to ascertain additional beneficial effects of other probiotic strains in MetS as well as the mechanisms by which such effects are exerted.

Study Type : Human Study

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