Abstract Title:

A new use ofGG administration in the NICU: colonized vancomycin-resistant enterococcus eradication in the gastrointestinal system.

Abstract Source:

J Matern Fetal Neonatal Med. 2020 Mar 24:1-7. Epub 2020 Mar 24. PMID: 32208789

Abstract Author(s):

Melek Buyukeren, Sule Yigit, Ayse Buyukcam, Ates Kara, Hasan Tolga Celik, Murat Yurdakok

Article Affiliation:

Melek Buyukeren


Enterococci are microbiota microorganisms that normally have low virulence; however, under some conditions they may cause community-acquired urinary tract and even hospital-acquired serious infections. Vancomycin-resistant enterococci (VRE) can cause aggressive infections in immunosuppressive patients; especially in newborns in intensive care units. Asymptomatic gastrointestinal system carriers are important sources of VRE. Asymptomatic patients colonized by VRE can infect both other patients and the environment. Prevention of gastrointestinal colonization of VRE is an important issue to prevent VRE infection, and for rational use of hospital source.This study was carried out at Hacettepe University, Faculty of Medicine in Newborn Intensive Care Unit between November 2015 and March 2017. The newborn infants who were find as colonized by VRE during weekly surveillance VRE rectal stool culture screening were taken into the study. A single dose of one million colonies ofGG (LGG®) was given to the study group daily. The probiotic supplement continued until consecutive three negative cultures were detected or maximum 6 months. Control group received conventional treatment.In the study group, VRE eradication was successful in 21 patients out of 22 within 6 months and 1 patient was still VRE positive at 6 months. In the control group, VRE was eradicated in 12 patients out of 23 and 11 patients continued to be colonized by VRE at 6 months. There was a statistically significant difference between the groups ( <.05).GG use is associated with early clearance of vancomycin-resistant enterococcus in newborn patients.

Study Type : Human Study

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